Success Story of Auburn University Professor Amarjit Mishra in the Area of Immune Pathways

The immensely complex scientific area of immunology has made a name for itself as a distinctive and original method of examining how living things work. A living thing’s immune system is recognised to be in charge of both the body’s defence against sickness and the avoidance of disease. People frequently conflate disease prevention and disease protection, although there is only a small distinction between the two. Prevention can relate to the periods when the body is exposed to unwelcome foreign particles, which may be living or nonliving, whereas protection refers to the maintenance of general well-being at all times. The area of study that focuses on this in-depth is immunology.

Amarjit Mishra Focuses the Attention on the Study of Immunology

It is a field of study that focuses on immune cells and host defence mechanisms in healthy and pathological contexts. The study of both innate and adaptive immune responses as well as procedures including pathogen identification, immune cell activation and recruitment, cytokine secretion, inflammation, and antibody formation are included in this. The pathways involved in the healthy operation of the body are frequently the subject of research on the immune system. It also encompasses the pathways connected to autoimmune disorders as well as the pathways connected to bodily inflammation. Amarjit Mishra, an assistant professor at Auburn University, is one of the researchers who has done outstanding work in examining the immunological pathways related to the respiratory system.

Assistant Professor Amarjit Mishra is an academician and scientist with knowledge of respiratory illnesses. Amarjit Mishra has a solid background in research pertaining to respiratory systems and has a higher education degree in the field of research from the esteemed Oklahoma Centre for Respiratory and Infectious Diseases of the Oklahoma State University. Inflammation has been recognised as one of the primary signs of immune system activity, and Amarjit has made great strides in understanding the immunological pathways utilising inflammation as a primary signal.

Amarjit Mishra Auburn University Guides About the functional Role of Myeloid Progenitor

One of the key studies carried out by Amarjit Mishra Auburn University is to understand the functional role of Myeloid Progenitor cells in obesity-associated airway inflammation. All organs receive a steady supply of myeloid cells through the circulation, which develop from hematopoietic stem cells in the bone marrow. The majority of leukocytes in peripheral blood are represented by them. It is known that these myeloid cells are differentiated offspring of common progenitors that emerged from bone marrow-derived hematopoietic stem cells. It was previously known from research that in obesity, myeloid cell accumulation and polarisation are encouraged to take on an immune-regulatory phenotype in order to restore metabolic and inflammatory homeostasis. However, these myeloid cells are also significant contributors to immune suppression and inflammation, which support the growth of tumours. For the development of airway inflammation in the event of obesity, Amarjit Mishra’s study concentrated on the immunological system linked to the proliferation and differentiation of dendritic cells – restricted common dendritic cells progenitor cells. According to Amarjit Mishra’s research, obesity worsens asthmatic airway inflammation by promoting the proliferation and differentiation of common dendritic cell progenitor cells, which improves the ability of the dendritic cells in the lung to stimulate adaptive immune responses. He worked to find new endogenous signalling pathways and druggable targets in adaptive immunity that control airway inflammation in obese people. The main foundation of his research was the synergistic integration of mouse models of experimental obesity-induced airway inflammation. He had also performed complex tests for biological analyses of immunological and progenitor cell functioning. The National Institutes of Health (NIH), in the United States, had granted funding to Amarjit Mishra’s initiative because of the importance of the study he had done. In this study, a group of researchers led by him were able to determine that the immunological pathway, now known as the Adam17-p38 MAPK-dependent pathway, plays a significant role in the inflammation of the airways associated with obesity.

Study About Early Stages of Acute Respiratory Distress Syndrome

His study in which he was able to pinpoint the regulatory pathways linked to the inflammation in the alveolar region was another significant contribution to the area of immunological pathways. The early stages of acute respiratory distress syndrome are known to cause significant inflammatory reactions in the alveolar region. Pneumonitis and pulmonary fibrosis have both been linked to inflammation in the alveolar area. As a result, his research has been able to advance the understanding of the mechanism of action that causes the lungs to become inflamed. As a member of the team, he was instrumental in identifying that MicroRNA-101 reduces lung fibrosis by preventing fibroblast activation and proliferation. The project received high praise from other researchers, and it was published in the reputable publication Journal of Biological Chemistry. A recent finding showed that miR-101 may be a therapeutic target for pulmonary fibrosis since it exhibits anti-fibrotic properties.

Amarjit Mishra has been conducting outstanding research in conjunction with researchers from all across the world. Because of his achievements, he was also chosen to be an Associate Editor for numerous prestigious journals, including BMC Immunology and EC Pulmonology and Respiratory Medicine. It is important to acknowledge the work that Amarjit Mishra has done, and he has been working to improve our understanding of biological pathways for the benefit of society.

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